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KMID : 0882420100780040485
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Korean Journal of Medicine
2010 Volume.78 No. 4 p.485 ~ p.489
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Regression of colon polyposis after aspirin medication
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Choi So-Young
Lee Hyun-Suk
Park Soo-Young
Jung Min-Kyu
Jeon Seong-Woo
Kim Sung-Kook
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Abstract
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There is considerable evidence that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of colorectal neoplasia. Unlike cyclooxygenase-1 (COX-1), which is constitutively expressed in the colon, COX-2 is overexpressed in colorectal cancers and adenomas in human. Aspirin inhibits the generation of prostaglandins by inhibiting both COX-1 and COX-2, which initiate prostaglandin synthesis. The chemopreventive effect of aspirin against the development of colorectal adenomas has been widely investigated. However, there is no agreement on the effect of aspirin on existing adenomas. We describe a case of colon polyposis that disappeared after aspirin medication.
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KEYWORD
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Aspirin, Colon, Polyp
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